Sinkin kuljetus verestä mitokondriaan . Artikkeli vuodelta 2011

https://www.sciencedirect.com/science/article/pii/S0162013411000304?via%3Dihub

Volume 105, Issue 5, May 2011, Pages 589-599

Review Article

Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells

Author links open overlay panelLeslie C.Costello^ab

Catherine C.Fenselau^bcRenty B.Franklin^abhttps://doi.org/10.1016/j.jinorgbio.2011.02.002

Outline

1. Abstract
2. Graphical abstract
3. Keywords
4. 1. Introduction
5. 2. The forms of zinc in mammalian biological systems (terminology issues)
6. 3. The concentration and forms of zinc delivered to mammalian cells in situ
7. 4. The cellular pools of zinc
8. 5. Cellular zinc uptake transport processes
9. 6. The Zn exchange kinetics of plasma membrane zinc uptake transport from ISF
10. 7. Interpretation: operation of a direct Zn-ligand → transporter exchange mechanism
11. 8. Mechanism of plasma membrane ZIP-family Zn uptake transport
12. 9. The direct Zn-ligand exchange kinetics of mitochondrial zinc uptake transport
13. 10. The direct Zn-ligand mechanism of zinc reactivity
14. 11. What do these collective studies demonstrate?
15. 12. The physiological zinc donor ligands in mammalian cells
16. 13. The impact of the direct Zn-ligand exchange mechanism on biomedical research and clinical application of zinc relationships
17. 14. Conclusion
18. Acknowledgement
19. References

 

Abstract

In addition to its critical role in normal cell function, growth, and metabolism, zinc is implicated as a major factor in the development and progression of many pathological conditions and diseases. Despite this importance of zinc, many important factors, processes, and mechanisms of the physiology, biochemistry, and molecular biology of zinc remain unknown. Especially important is the unresolved issue regarding the mechanism and process of the trafficking, transport, and reactivity of zinc in cells; especially in mammalian cells. This presentation focuses on the concept that, due to the existence of a negligible pool of free Zn²⁺ ions in the mammalian cell environment, the trafficking, transport and reactivity of zinc occurs via a direct exchange of zinc from donor Zn-ligands to acceptor ligands. This Zn exchange process occurs without the requirement for production of free Zn²⁺ ions. The direct evidence from mammalian cell studies is presented in support of the operation of the direct Zn-ligand exchange mechanism. The paper also provides important information and conditions that should be considered and employed in the conduct of studies regarding the role and effects of zinc in biological/biomedical research; and in its clinical interpretation and application.

Graphical abstract

We show that the transport, trafficking, and reactivity of zinc occur via a direct Zn ligand exchange process.